"Make Us Whole" is actually a psychic plea from the incomplete Brethren Moon, if not a general impulse from Red Markers to coax psychically vulnerable people to succumbing to the infection and becoming first Necromorphs and then a Brethren Moon. The revelations of the true nature of Markers and Necromorphs actually go some way toward explaining the Continuity Snarl between the first and second games:. Hence, the thing is probably, actually dead. When you kill the Moon, you do so by literally ripping its organs out in its "head" region, so if much smaller ones need organs to live, of course a moon-sized one needs them. Smaller human-sized Necromorphs can get away with having no dedicated organ systems, while city-sized ones like Nexuses need them to survive, like how cutting a simple starfish's arm off will be an impairment while doing the same to a human will kill them. No other Necromorphs have needed those, so why does this one? However, it's a case of Square-Cube Law and foreshadowing. 
During the Nexus boss fight, you are Swallowed Whole, and enter what appears to be a digestive system. Dozens of civilizations have been destroyed by Convergence and humanity is just the next one in the cycle of an endless graveyard. In Dead Space 3, it means that space is literally dead. Here's one for the entire series: In Dead Space 1, the name "Dead Space" was named for the Marker's field of power and the whole zombie apocalypse. 
Notice the moon in the background of some promotional posters? It's the final boss.
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